TLS Online TPP Program

#Question id: 565


A transition-state analog:

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. is less stable when binding to an enzyme than the normal substrate.

  2. resembles the active site of general acid-base enzymes.

  3. resembles the transition-state structure of the normal enzyme-substrate complex.

  4. stabilizes the transition state for the normal enzyme-substrate complex.

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TLS Online TPP Program

#Question id: 7165

#Unit 5. Developmental Biology

Embryonic induction, the influence of one group of cells on another group of cells, plays a critical role in embryonic development. In 1924, Hans Spemann and Hilde Mangold transplanted a piece of tissue that influences the formation of the notochord and neural tube, from the dorsal lip of an amphibian embryo to the ventral side of another amphibian embryo. If embryonic induction occurred, which of the following observations justifies the claim of embryonic induction?

TLS Online TPP Program

#Question id: 7166

#Unit 5. Developmental Biology

Just prior to the onset of gastrulation in an embryo, the "organizer" cells are specified. If you were to experimentally block the specification of these cells, what would you expect the result to be in the developing embryo?

TLS Online TPP Program

#Question id: 7167

#Unit 5. Developmental Biology

The following experiment is designed to study the role of several hormones in the regulation of metamorphosis in frogs.

Group #

Treatment

Days to Metamorphosis

1

Saline

30

2

Prolactin

> 100

3

TSH

15

4

Thyroxine

10

5

Corticosterone

30

6

Thyroxine + Corticosterone

5

7

Prolactin + TSH

30

8

Thyroid gland removed

> 100

These results suggest which of the following about prolactin (group 2 and group 7) at the dose tested?

TLS Online TPP Program

#Question id: 7168

#Unit 5. Developmental Biology

Which one of the following signaling pathways will best support the mediolateral intercalation in the formation of the primitive streak in chick?

TLS Online TPP Program

#Question id: 7169

#Unit 5. Developmental Biology

Before oogenesis begins, the oogonium divides four times with incomplete cytokinesis, giving rise to 16 interconnected cells in drosophila. These 16 germline cells, along with a surrounding epithelial layer of somatic follicle cells, constitute the egg chamber in which the oocyte will develop. These germline cells include:

TLS Online TPP Program

#Question id: 7170

#Unit 5. Developmental Biology

Following statements are regarding to maternally provided mRNAs—hunchback and caudal, are critical for patterning the anterior and posterior regions of the body plan, respectively.

A. These two mRNAs are synthesized by the nurse cells of the ovary and transported to the oocyte, where they are distributed ubiquitously throughout the syncytial blastoderm.

B. Translation of the hunchback and caudal mRNAs is repressed by the diffusion gradients of Bicoid and Nanos proteins, respectively.

C. Bicoid binds to a specific region of caudal’s 3′UTR. Here, it binds Bin3, a protein that stabilizes an inhibitory complex that prevents the binding of the mRNA 5′ cap to the ribosome. By recruiting this translational inhibitor, Bicoid prevents translation of caudal in the anterior of the embryo.

D. Nanos protein prevents translation of the hunchback message. Nanos in the posterior of the embryo forms a complex with several other ubiquitous proteins, including Pumilio and Brat. This complex binds to the 3′UTR of the hunchback message, where it recruits d4EHP and prevents the hunchback message from attaching to ribosomes.

Which of the following statements are true?