Aneuploids may arise through nondisjunction, the failure of homologous chromosomes or sister chromatids to separate in meiosis. Following some statement are correct.

A)  Meiosis I non-disjunction leads to produce all gamete become aneuploidy

B) Meiosis II non-disjunction leads to produce half of gametes n+1 other half normal haploid

C) Meiosis I non-disjunction leads to produce half of gametes n+1 other half n-1

D) Either meiosis I or meiosis II non-disjunction leads to produce all aneuploidy gamete

#Question id: 4076

#Unit 3. Fundamental Processes

RNA-binding proteins

a. can be identified by chromatography of UV irradiated nuclear extracts over oligo-dT columns.

b. can be identified by sequence homology to known RNA-binding domains.

c. have a conserved structure as seen by X-ray crystallographic analysis.

d. alter the secondary structure of pre-mRNAs, which decreases interactions with other RNAs or proteins.

e. always remain in the nucleus.

#Question id: 4077

#Unit 3. Fundamental Processes

Which of the following is (are) associated with most polyadenylation events?

a. cleavage of the 5´ end of the RNA molecule

b. an assembly of a large, multiprotein complex

c. the AAUAAA site upstream of where polyadenylation will occur

d. a GU-rich or U-rich region near the cleavage site

e. slow addition of A residues followed by rapid addition of 200 to 250 more A residues

#Question id: 4078

#Unit 3. Fundamental Processes

Which of the following is (are) required for splicing to occur?

a. two transesterification reactions

b. intact, naturally occurring introns

c. formation of a lariat like structure

d. a branch-point G residue

#Question id: 4079

#Unit 3. Fundamental Processes

What is the evidence that pre-mRNAs are not synthesized unless machinery for processing is properly positioned?

#Question id: 4080

#Unit 3. Fundamental Processes

How the location of exons and introns within a gene are determined?

#Question id: 4081

#Unit 3. Fundamental Processes

Which of the following regulatory scenarios of cell-type-specific expression of fibronectin isoforms in humans is (are) consistent with information on known splicing factors?

a. A Tra-like splicing factor expressed in fibroblasts is required for inclusion of EIIIA and EIIIB exons.

b. An Sxl-like splicing factor is required in hepatocytes for exclusion of EIIIA and EIIIB exons.

c. A Tra-2-like factor enhances binding of the cleavage/polyadenylation complex in fibroblasts.

d. A Dsx-like protein is required to inhibit transcription of the fibronectin gene.