TLS Online TPP Program

#Question id: 5804


The gene that is mutated in cases of cystic fibrosis encodes an ion transporter protein normally expressed in the respiratory and digestive tracts along with other locations. Individuals homozygous for the most common mutation in this gene (ΔF508) died at very early ages prior to the advent of advanced medical intervention. Despite this, the mutation exists at relatively high frequency in populations of European descent. One potential explanation is that heterozygotes for such mutations may be relatively immune to the lethal effects of diseases such as typhoid fever. Which statement below is most accurate?

#Unit 8. Inheritance Biology
  1. The ΔF508 cystic fibrosis mutation is a beneficial mutation.

  2. The ΔF508 cystic fibrosis mutation is a lethal mutation.

  3. The ΔF508 cystic fibrosis mutation is a conditional mutation.

  4. The ΔF508 cystic fibrosis mutation is a neutral mutation