The gene that is mutated in cases of cystic fibrosis encodes an ion transporter protein normally expressed in the respiratory and digestive tracts along with other locations. Individuals homozygous for the most common mutation in this gene (ΔF508) died at very early ages prior to the advent of advanced medical intervention. Despite this, the mutation exists at relatively high frequency in populations of European descent. One potential explanation is that heterozygotes for such mutations may be relatively immune to the lethal effects of diseases such as typhoid fever. Which statement below is most accurate?

TLS Online TPP Program

#Question id: 27957

#Unit 1. Molecules and their Interaction Relevant to Biology

Bicarbonate + Pyruvate→ Oxaloacetate

a. This reaction catalyzed by pyruvate carboxylase

b. This reaction catalyzed by carbonic anhydrases

c. Uses biotin as cofactor of pyruvate carboxylase

d. Uses biotin as cofactor ofby carbonic anhydrases

Which of the following is true about the given reaction

TLS Online TPP Program

#Question id: 27958

#Unit 1. Molecules and their Interaction Relevant to Biology

The overall equation for Gluconeogenesis is

TLS Online TPP Program

#Question id: 27959

#Unit 1. Molecules and their Interaction Relevant to Biology

Amino acids can undergo net conversion to glucose and are said to be glucogenic and Glucogenic Amino Acids, are Grouped by Site of Entry

a. Alanine, Cysteine, Glycine, Serine, Threonine, Tryptophan, can undergo glucose formation by Pyruvate 

b. Arginine, Glutamate, Glutamine, Histidine, Proline can undergo glucose formation by α-Ketoglutarate

c. Isoleucine*, Methionine, Threonine, Valine can undergo glucose formation by Succinyl-CoA

d. Asparagine, Aspartate can undergo glucose formation by Oxaloacetate

Choose which of the following is correct

TLS Online TPP Program

#Question id: 27960

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following phenomenon is directly related to repair  

TLS Online TPP Program

#Question id: 27961

#Unit 1. Molecules and their Interaction Relevant to Biology

Conversion of Glucose 6-phosphate →  Ribulose 5-phosphate in oxidative phase involves

(a) 2NADP

(b) Removal of 1 CO2

(c) Uses G6PD as enzyme 

(d) No 2NADP is required

TLS Online TPP Program

#Question id: 27962

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of following is true regarding the Transketolase and Transaldolase

a. Transketolase catalyzes the transfer of a two-carbon fragment from a ketose donor to an aldose acceptor with TPP

b. Transketolase catalyzes the transfer of a three-carbon fragment from a ketose donor to an aldose acceptor with TPP

c. Transaldolase catalyses the transfer of a two-carbon fragment

d. Transaldolase catalyses the transfer of a three-carbon fragment