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TLS Online TPP Program

#Question id: 5807

Which of the following would be an example of a germline mutation?

#Unit 8. Inheritance Biology

  1. Exposure to excessive UV radiation causes changes in the DNA of a skin cell, leading to basal cell carcinoma (skin cancer).

  2. In a very early human embryo, a mistake in mitosis causes loss of a Y chromosome in one daughter cell. The resulting child is a fertile male who is chromosomally partially male (XY) and partially female with Turner's syndrome (XO).

  3. A man with normal chromosomes has a hip X-ray without a protective shield. Ten months later, his wife gives birth to a child with a chromosomal deletion.

  4. An embryo missing one copy of the third chromosome is miscarried very early in pregnancy.

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TLS Online TPP Program

#Question id: 2990

#Unit 2. Cellular Organization

Mitotic CDK complexes are maintained in an inactive state through inhibitory phosphorylation of the CDK subunit. Two highly conserved tyrosine and threonine residues in mammalian CDKs are subject to regulated phosphorylation.

Gene

  Mutant phenotypes

A. Wee1

i. the cell does not divide but continues to grow

B. CAK kinase

ii. mitotic cyclins are inactivated

C. cdc25 phosphatase

iii. premature entry into mitosis

The following table enlists genes and phenotypes observed on mutation of these genes but not correctly matched. Which one of the following combinations is correctly matched ?
TLS Online TPP Program

#Question id: 2991

#Unit 2. Cellular Organization

Early observations of a cultured cell line indicated that the cells did not exhibit either density-dependent inhibition or anchorage dependence. What do these observations suggest about this cell line?
TLS Online TPP Program

#Question id: 2992

#Unit 2. Cellular Organization

DNA was isolated from three different cell types of the same organism, the relative DNA content for each type was determined, and the results were plotted on the graph shown in the figure below. Refer to the graph to answer the following questions. Which sample of DNA might be from a cell that stopped the process of cell division in G0 phase of the cell cycle prior to meiosis?
TLS Online TPP Program

#Question id: 2993

#Unit 2. Cellular Organization

During meiosis, a defect occurs in a cell that results in the failure of spindle microtubules binding at the kinetochores. Which of the following statements describes the most likely result of such a defect?
TLS Online TPP Program

#Question id: 2994

#Unit 2. Cellular Organization

If a cell has completed meiosis I and the first cytokinesis, and is just beginning meiosis II, which of the following is an appropriate description of its genetic contents?
TLS Online TPP Program

#Question id: 2995

#Unit 2. Cellular Organization

 Which of the following incorrect pair?