In the resting state, kinases CK1 and GSK3, sequentially phosphorylate β-catenin on:

TLS Online TPP Program

#Question id: 33227

#Unit 1. Molecules and their Interaction Relevant to Biology

An uncatalyzed keto– enol tautomerization reaction occurs quite slowly as a result of the high free energy of its carbanion-like transition state called as

TLS Online TPP Program

#Question id: 33228

#Unit 1. Molecules and their Interaction Relevant to Biology

If velocity of the reaction is increased by proton abstraction by a species, mechanism is called as

TLS Online TPP Program

#Question id: 33229

#Unit 1. Molecules and their Interaction Relevant to Biology

The effects of pH on enzymes depends on a combination of factors: 

(a) Most enzymes are active within only a narrow pH range, typically 5 to 9. 

(b) the ionization states of the amino acid residues involved in the catalytic activity of the enzyme

(c) the variation of protein structure (usually significant only at extremes of pH).

Which of the above is correct

TLS Online TPP Program

#Question id: 33230

#Unit 1. Molecules and their Interaction Relevant to Biology

The pH dependence of the rate of the reaction catalyzed by fumarase produces the following curve. Which amino acid/s likely to be present in the active site

TLS Online TPP Program

#Question id: 33231

#Unit 1. Molecules and their Interaction Relevant to Biology

Which character makes concerted acid–base catalysis a common enzymatic mechanism?

TLS Online TPP Program

#Question id: 33232

#Unit 1. Molecules and their Interaction Relevant to Biology

In RNase A