TLS Online TPP Program

#Question id: 32223


What is the purpose of N-linked Glycosylation?

#Unit 2. Cellular Organization
  1. N-linked oligosaccharide establish a “glyco-code” that marks the progression of protein unfolding.
  2. The presence of oligosaccharides tends to make a glycoprotein more susceptible to digestion by proteolytic enzymes.
  3. N-linked glycosylation making folding intermediates more soluble, thereby promoting their aggregation. 
  4. A small N-linked oligosaccharide protruding from the surface of a glycoprotein can limit the approach of other macromolecules to the protein surface.
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TLS Online TPP Program

#Question id: 864

#Unit 1. Molecules and their Interaction Relevant to Biology

Which one is not the appropriate function of Heat Shock Proteins;

TLS Online TPP Program

#Question id: 865

#Unit 1. Molecules and their Interaction Relevant to Biology

In autophagy, the endoplasmic reticulum (ER) first gives rise to a cup-shaped, membranous cisterna called the______

TLS Online TPP Program

#Question id: 866

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is known as Sanger’s reagent

TLS Online TPP Program

#Question id: 867

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the correct diseases with their precursors

Disease

Protein or precursor involved in disease

1. Cystic fibrosis

a. Prion protein

2. Creutzfeldt–Jakob disease

b. CFTR

3. Familial hypercholesterolaemia

c. LDL receptor

4. fatal familial insomnia

d. β-amyloid protein

5. Alzheimer’s disease

e. β-hexosaminidase

TLS Online TPP Program

#Question id: 868

#Unit 1. Molecules and their Interaction Relevant to Biology

Which statements is incorrect about ‘The chaperonin-assisted catalysis of protein folding’

A. The non-cooperative nature of ATP binding establishes GroEL as an allosteric enzyme.

B. In GroEL with a total of 14 subunits in two heptameric rings are observed.

C. In vivo GroES is composed of seven identical subunits whilst GroEL is composed of 14 larger subunits.

D. Gro-EL being called chaperonin60 (cpn60) and Gro-ES chaperonin10 (cpn10).

TLS Online TPP Program

#Question id: 869

#Unit 1. Molecules and their Interaction Relevant to Biology

Which statements are correct regarding protein folding

A. Many molecular chaperones were first described as heat shock proteins (Hsp) because Their rate of synthesis is increased at elevated temperatures

B. The renaturation of a denatured protein in vitro may not entirely mimic the folding of a protein in vivo.

C. Molecular chaperones are essential proteins that bind to only partially folded polypeptide chains.

D. Molecular chaperones function to lift folding polypeptides out of the false minima in their folding funnel.