TLS Online TPP Program

#Question id: 32343


At intermediate concentrations of actin subunits, the plus end of the filament remains in the T conformation, while the minus end adopts the D conformation because:

#Unit 2. Cellular Organization
  1. Rate of subunit addition to be slower than nucleotide hydrolysis at the plus end, but faster than nucleotide hydrolysis at the minus end.
  2. Rate of subunit dissociation to be faster than nucleotide hydrolysis at the plus end, but slower than nucleotide hydrolysis at the minus end.
  3. Rate of subunit dissociation to be slower than nucleotide hydrolysis at the plus end & minus end.
  4. Rate of subunit addition to be faster than nucleotide hydrolysis at the plus end, but slower than nucleotide hydrolysis at the minus end.
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TLS Online TPP Program

#Question id: 4534

#Unit 3. Fundamental Processes

The yeast Saccharomyces cerevisiae divides by budding: instead of dividing to produce two identical daughter cells, the so-called mother cell buds to produce a daughter cell, The HO gene is expressed only in mother cells and only at a certain point in the cell cycle,

1. SBF

I- Which is active only during the G1-S transition of the cell cycle.

2. SWI5

II-Which acts only in the mother cell.

III- Recruit nucleosome modifiers

TLS Online TPP Program

#Question id: 4535

#Unit 3. Fundamental Processes

The activators bind—and the enhanceosome forms—in a highly cooperative manner, ensuring that all three activators must be present. The following are three ways the regulators might be binding cooperatively:

I- Through direct protein–protein interactions between them

II- By changes in the DNA caused by binding of one protein helping binding of another;

III- By the fact that the activators all interact simultaneously with the coactivator.

TLS Online TPP Program

#Question id: 4536

#Unit 3. Fundamental Processes

The human b-interferon gene is activated in cells upon viral infection through some activators, EXCEPT one

TLS Online TPP Program

#Question id: 4537

#Unit 3. Fundamental Processes

The enhancer DNA is __, but once the activators are bound it is relatively  , HMGA1 the DNA and thus helps the final structure form.

TLS Online TPP Program

#Question id: 4538

#Unit 3. Fundamental Processes

We first consider a generic case. Gene A is controlled by four signals (1, 2, 3, and 4), each working through a separate activator (activators 1, 2, 3, and 4). Gene B is controlled by three signals (3, 5, and 6), working through activators 3, 5, and 6. It shows-

TLS Online TPP Program

#Question id: 4539

#Unit 3. Fundamental Processes

The yeast S. cerevisiae exists in three forms: two haploid cells of different mating types—a and alpha and the diploid formed when an a and an a cell mate and fuse. The a cell and the a cell each encodes cell-type-specific regulators: a cells make the regulatory protein a1, and alpha cells make the proteins alpha1 and alpha2. A fourth regulatory protein, called Mcm1, is also involved in regulating the mating-type-specific genes (and many other genes) and is present in both cell types which shows Combinatorial Control.

The arrangement of regulators at the promoters of a-specific genes and a-specific genes is

cell type:

gene regulatory proteins:

target genes:

1.a cell (haploid)

a1

Mcm1

aSG

alphaSG

2.αlpha cell (haploid)

alpha 1

alpha 2

Mcm2

hSG

3.a/αlpha cell (diploid)

a1

Mcm2

alpha2