TLS Online TPP Program

#Question id: 7124


Neural crest cells that follow a dorso-lateral route of migration under the skin will become melanocytes; how is their differentiation into melanocytes triggered during their migration?

#Unit 5. Developmental Biology
  1. The neural crest cells are already determined to become melanocytes before they leave the neural tube
  2. N-cadherin and E-cadherin are lost from the neural crest cells when they initiate their migration, and this signals the cells to become melanocytes.
  3. BMP and noggin control the fate of neural crest cells.
  4. The cells in the skin express a ligand (stem cell factor, SCF, also known as Steel) on their surface, which interacts with a receptor (Kit, also known as white spotting) on the surface of the neural crest derived cells; this interaction triggers their differentiation as melanocytes.