TLS Online TPP Program

#Question id: 7127


The immunoglobulin genes are expressed in B-cells, and the b-globin gene is expressed in red blood cells. What manipulations might be carried out to get the b-globin gene to be expressed in B-cells?

#Unit 5. Developmental Biology
  1. The coding region of an immunoglobulin gene could be combined with the cis-regulatory region of the b-globin genes, and this artificial gene would then express b-globin in B-cells.
  2. The cis-regulatory region of the b-globin gene could be inserted into B-cells, which would then express their own version of the b-globin gene.
  3. The cis-regulatory region of an immunoglobulin gene could be combined with the coding region of the b-globin genes, and this artificial gene would then express b-globin in B-cells.
  4. The transcription factors GATA-1 and GATA-2 (which activate the b-globin gene in erythrocytes) could be introduced into B-cells, which would then express their own copy of the b-globin gene.