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TLS Online TPP Program

#Question id: 7128

Imagine that in an attempt to get the â-globin gene to be expressed in B-cells, the transcription factors (GATA-1 and GATA-2) known to control the â-globin gene in erythrocytes were introduced into B-cells, yet the â-globin gene was not expressed. What is a likely explanation for this result?

#Unit 5. Developmental Biology
  1. The erythrocyte transcription factors are degraded rapidly in the B-cell, and so cannot act on the â-globin gene.
  2. The â-globin gene in the B-cells is packaged into heterochromatin, and the erythrocyte transcription factors are insufficient to remodel that chromatin into an active state.
  3. Erythrocyte transcription factors cannot interact with their target DNA sequences in B-cells, even though those sequences are present and accessible.
  4. Even though the necessary erythrocyte-specific transcription factors are now present in the B-cells, the general transcription factors required for â-globin gene expression would not be present
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TLS Online TPP Program

#Question id: 30094

#Unit 1. Molecules and their Interaction Relevant to Biology

Name the genetic disorder which is caused by the deficiency of enzyme HGPRT?
TLS Online TPP Program

#Question id: 14089

#General Aptitude

 If the orthocentre and the centroid of a triangle are the same, then the triangle is :
TLS Online TPP Program

#Question id: 31389

#Unit 4. Cell Communication and Cell Signaling

In modern cancer therapy, small-molecule anticancer drugs are designed to inhibit the products of specific cancer-critical genes. If you were searching for such molecules, you design inhibitors for the products of:
TLS Online TPP Program

#Question id: 2461

#Unit 2. Cellular Organization

Which of the following properties is not shared by all myosins?
TLS Online TPP Program

#Question id: 7167

#Unit 5. Developmental Biology

The following experiment is designed to study the role of several hormones in the regulation of metamorphosis in frogs.

Group #

Treatment

Days to Metamorphosis

1

Saline

30

2

Prolactin

> 100

3

TSH

15

4

Thyroxine

10

5

Corticosterone

30

6

Thyroxine + Corticosterone

5

7

Prolactin + TSH

30

8

Thyroid gland removed

> 100

These results suggest which of the following about prolactin (group 2 and group 7) at the dose tested?