TLS Online TPP Program

#Question id: 7131


What is globin gene switching?

#Unit 5. Developmental Biology
  1. Globin gene switching refers to the switching on of the globin genes during erythrocyte differentiation.
  2. Globin gene switching refers to the switching from a-globin to b-globin, so that a2b2 hemoglobin can be made.
  3. Globin gene switching refers to the molecular basis for the genetic disease, sickle cell anemia.
  4. Globin gene switching refers to the transition, during fetal development, from the production of hemoglobin containing e-globin, to g-globin, to b-globin.
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TLS Online TPP Program

#Question id: 33900

#Unit 2. Cellular Organization

A. Bacterial genome have many independent chromosomal domains
B. Bacterial genome is circular and have many intertangled domains 
C. Each domain consists of 40 kilobases (k2. of DNA 
D. The existence of separate domains donot permit different degrees of supercoiling to be maintained in different regions of the genome.

Find true and false

TLS Online TPP Program

#Question id: 33904

#Unit 2. Cellular Organization

A. The bacterial nucleoid is 80% DNA by mass.
B. Bacteria have similar morphological features as of eukaryotic chromosomes, 
C. Bacterial genomes are organized into definite substructures within the cell. 
D. Bacterial Protein HU is a dimer that condenses DNA, possibly wrapping it into a beadlike structure.

Find true and false

TLS Online TPP Program

#Question id: 33905

#Unit 2. Cellular Organization

E. coli DNA in vivo corresponds to an average density of 1 negative superhelical turn/200 bp it means it has 

TLS Online TPP Program

#Question id: 33906

#Unit 2. Cellular Organization

Which is correct combination of statements

A. Bacterial genome has independent sets of domains and each domain consists of a loop of DNA.
B. Presence of domain in genome can be analyzed by EtBR intercalation and DNase treatment 
C. Early data suggested that each domain consists of 10kb-40 kb of DNA

TLS Online TPP Program

#Question id: 33907

#Unit 2. Cellular Organization

A circular DNA molecule with 580,070 bp. Calculate the molecular weight and contour length (when relaxed) of this molecule. What is Lko for the Mycoplasma chromosome? If σ=-  0.06, what is Lk?

TLS Online TPP Program

#Question id: 33908

#Unit 2. Cellular Organization

How is the linking number altered if one DNA strand is broken