TLS Online TPP Program

#Question id: 7135


Recently, it was reported that adult, differentiated cells can be made to behave as pluripotent stem cells by the introduction of a few genes, one of which was Oct4. What was the rationale for this experiment?

#Unit 5. Developmental Biology
  1. Oct4 expression is one of the requisites for the maintenance of pluripotent embryonic stem cells in culture.
  2. the Oct4 gene produces a cell-cell signaling protein that is used by stem cells to stimulate cell division
  3. Oct4 is only expressed in embryonic stem cells, and so its expression automatically reverses any differentiation that may have gone on in a cell
  4. the Oct4 gene is lost from differentiated cells through a genomic rearrangement, and its reintroduction reverses that rearrangement and hence differentiation
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TLS Online TPP Program

#Question id: 19735

#Unit 3. Fundamental Processes

In mammals, six telomeric proteins (TRF1, TRF2, Rap1, TIN2, TPP1, and POT1) comprises a complex which of the following is incorrect regrarding these telomeric protein
a) TRF1, TRF2, Rap1, binds to double stranded of DNA
b) TIN2 does not binds to DNA at all
c) POT1 binds to the GT tail extended by telomerase
d) TIN2 interacts with the two duplex telomeric DNA-binding proteins TRF1 and TRF2 as well as with TPP1

TLS Online TPP Program

#Question id: 19736

#Unit 3. Fundamental Processes

Which of the following shelterin protein interacts with the two duplex telomeric DNA-binding proteins TRF1 and TRF2 as well as with TPP1

TLS Online TPP Program

#Question id: 19737

#Unit 3. Fundamental Processes

Choose the incorrect statement regarding telomerase 

TLS Online TPP Program

#Question id: 19738

#Unit 3. Fundamental Processes

For the synthesis of telomere by telomerase require Only 

TLS Online TPP Program

#Question id: 19739

#Unit 3. Fundamental Processes

Telomeric RNA component in yeast and human are encoded by

TLS Online TPP Program

#Question id: 19740

#Unit 3. Fundamental Processes

Choose the correct statement
a) Telomeric RNA component is encoded by TLC1 in yeast, and hTERC in humans
b) Telomeric RNA component is encoded by hTERC in yeast, and TLC1 in humans
c) Telomerase protein component with catalytic activity is encoded by EST2 in yeast, hTERT in humans
d) Telomerase protein component with catalytic activity is encoded by hTERT in yeast, EST2 in humans