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TLS Online TPP Program

#Question id: 7135

Recently, it was reported that adult, differentiated cells can be made to behave as pluripotent stem cells by the introduction of a few genes, one of which was Oct4. What was the rationale for this experiment?

#Unit 5. Developmental Biology
  1. Oct4 expression is one of the requisites for the maintenance of pluripotent embryonic stem cells in culture.
  2. the Oct4 gene produces a cell-cell signaling protein that is used by stem cells to stimulate cell division
  3. Oct4 is only expressed in embryonic stem cells, and so its expression automatically reverses any differentiation that may have gone on in a cell
  4. the Oct4 gene is lost from differentiated cells through a genomic rearrangement, and its reintroduction reverses that rearrangement and hence differentiation
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TLS Online TPP Program

#Question id: 28043

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following statement holds true for the hydrogen and hydrophobic interaction in protein folding 
(1) The Hydrophobic Effect Has the minimal Influence on Protein Stability
(2) The Hydrophobic Effect Has the Greatest Influence on Protein Stability
(3) Hydrogen bonds, which are central features of protein structures, make only minor contributions to protein stability
(4) Hydrogen bonds, which are central features of protein structures, makes major contributions to protein stability
TLS Online TPP Program

#Question id: 28044

#Unit 1. Molecules and their Interaction Relevant to Biology

Which one of the following is INCORRECT about protein structures?
TLS Online TPP Program

#Question id: 28045

#Unit 1. Molecules and their Interaction Relevant to Biology

Native proteins are 
TLS Online TPP Program

#Question id: 28046

#Unit 1. Molecules and their Interaction Relevant to Biology

Protein stability depend on interactions which one of the following is correctly representing the increasing order of contribution
TLS Online TPP Program

#Question id: 28047

#Unit 1. Molecules and their Interaction Relevant to Biology

Protein A will fold into its native state only when protein B is also present in the solution. However, protein B can fold itself into native confirmation without the presence of protein A. Which of the following is true? 
TLS Online TPP Program

#Question id: 28048

#Unit 1. Molecules and their Interaction Relevant to Biology

As folding progresses which of the following does not take place?