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TLS Online TPP Program

#Question id: 34134

A 45-year-old male with type 2 diabetes mellitus presents for routine follow-up. His fasting blood glucose is 110 mg/dL, but his HbA1c is 8.5%. Which of the following best explains the discrepancy between his fasting glucose and HbA1c?

#Unit 7. System Physiology – Animal
  1. The patient has anemia, reducing the lifespan of red blood cells and increasing HbA1c levels.
  2. The patient likely has frequent postprandial hyperglycemia despite normal fasting levels.
  3. HbA1c reflects glycemic control only in the 24–48 hours preceding measurement.
  4. Insulin therapy artificially increases HbA1c by promoting glycation of hemoglobin
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TLS Online TPP Program

#Question id: 12490

#Unit 8. Inheritance Biology

Tay-Sachs disease shows autosomal recessive inheritance. Parents of a newly diagnosed affected child are referred for genetic counselling. It would be correct to tell them that:
TLS Online TPP Program

#Question id: 12491

#Unit 8. Inheritance Biology

Phenylketonuria shows autosomal recessive inheritance with an incidence of 1 in 10000. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?
TLS Online TPP Program

#Question id: 12492

#Unit 8. Inheritance Biology

A young man with phenylketonuria, who was successfully treated following diagnosis on newborn screening, is planning to start a family with his healthy, unaffected, and unrelated partner, who has no family history of phenylketonuria . Phenylketonuria shows autosomal recessive inheritance with an incidence of 1 in 10 000. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?
TLS Online TPP Program

#Question id: 12493

#Unit 8. Inheritance Biology

Cystic fibrosis shows autosomal recessive inheritance with an incidence of 1 in 2500. The unaffected brother of an affected girl is referred for genetic counseling. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?
TLS Online TPP Program

#Question id: 12494

#Unit 8. Inheritance Biology

Hunter syndrome is a rare form of mucopolysacchararidosis that differs from all other forms in that it shows X-linked recessive inheritance. A woman with two affected brothers is referred for genetic counselling. Which of the following is correct?
TLS Online TPP Program

#Question id: 12495

#Unit 8. Inheritance Biology

Haemophilia A is a severe coagulation disorder that shows X-linked recessive inheritance. Red-green colour blindness also shows X-linked recessive inheritance. A man with both haemophilia A and colour blindness is referred for genetic counseling. Assume that his partner is not a carrier of either of these conditions. Which of the following is correct?