TLS Online TPP Program

#Question id: 34143


Which of the following best explains how normal plasma oxytocin levels at the onset of labor can still result in powerful uterine contractions?

#Unit 7. System Physiology – Animal
  1. The uterus begins secreting its own oxytocin, which inhibits progesterone and directly stimulates the fetal adrenal cortex.
  2. The descent of the fetus stimulates a hypothalamic feedback loop that rapidly increases systemic oxytocin to supraphysiologic levels.
  3. There is a marked upregulation of uterine oxytocin receptors at term, making the myometrium hypersensitive even to baseline oxytocin levels, initiating a positive feedback loop.
  4. Oxytocin receptors on the cervix and vagina directly stimulate the anterior pituitary to secrete oxytocin during early labor.