A scientist finds that infusion of growth hormone into the median eminence of the hypothalamus in experimental animals inhibits the secretion of growth hormone and concludes that this proves that growth hormone feeds back to inhibit GHRH secretion. Do you accept this conclusion?

#Question id: 4476

#Unit 3. Fundamental Processes

Regulatory elements include promoter proximal elements, upstream activator sequences (UASs), enhancers, and a series of other element

#Question id: 4477

#Unit 3. Fundamental Processes

The large subunit of Pol II has a carboxy-terminal domain (CTD), which is referred to as the “tail”. The CTD contains a series of repeats of the heptapeptide sequence is;

#Question id: 4478

#Unit 3. Fundamental Processes

In prokaryotes during abortive initiation, the polymerase synthesizes a series of short transcripts. In eukaryotes, promoter escape involves;

#Question id: 4479

#Unit 3. Fundamental Processes

The stepwise assembly of the Pol II preinitiation complex

#Question id: 4480

#Unit 3. Fundamental Processes

The reason for TBP’s unorthodox recognition mechanism is

#Question id: 4481

#Unit 3. Fundamental Processes

Choose correct statements about recognition mechanism of TBP ;

A. TBP causes the minor groove to be widened to an almost flat conformation

B. It also bends the DNA by an angle of ~120o

C. The interaction between TBP and DNA involves maximum number of hydrogen bonds between the protein and the edges of the base.

D. Much of the specificity is imposed by two pairs of phenylalanine side chains that intercalate between the base pairs at either end of the recognition sequence and drive the strong bend in the DNA.