#Question id: 7170

Following statements are regarding to maternally provided mRNAs—hunchback and caudal, are critical for patterning the anterior and posterior regions of the body plan, respectively.

A. These two mRNAs are synthesized by the nurse cells of the ovary and transported to the oocyte, where they are distributed ubiquitously throughout the syncytial blastoderm.

B. Translation of the hunchback and caudal mRNAs is repressed by the diffusion gradients of Bicoid and Nanos proteins, respectively.

C. Bicoid binds to a specific region of caudal’s 3′UTR. Here, it binds Bin3, a protein that stabilizes an inhibitory complex that prevents the binding of the mRNA 5′ cap to the ribosome. By recruiting this translational inhibitor, Bicoid prevents translation of caudal in the anterior of the embryo.

D. Nanos protein prevents translation of the hunchback message. Nanos in the posterior of the embryo forms a complex with several other ubiquitous proteins, including Pumilio and Brat. This complex binds to the 3′UTR of the hunchback message, where it recruits d4EHP and prevents the hunchback message from attaching to ribosomes.

Which of the following statements are true?