Normally, the FgfR3 protein (a receptor tyrosine kinase) is activated by a fibroblast growth factor and signals the chondrocytes to stop dividing and begin differentiating into cartilage. This signal is mediated by the Stat protein, which is phosphorylated by activated FgfR3 and then translocated into the nucleus. Inside the nucleus, Stat activates the genes encoding a cell cycle inhibitor, the p21 protein. The mutation in FgfR3 causes the lethal condition thanatophoric dysplasia. This condition may be achieved by:

A. Mutations in the extracellular domain of the FgfR3 protein

B. Mutations in the tyrosine kinase intracellular domain of the FgfR3 protein

C. Mutations in the transmembrane domain of the FgfR3 protein

Which of the following is correct?

TLS Online TPP Program

#Question id: 34167

#Unit 7. System Physiology – Animal

I. The adrenal medulla does not regenerate, but when the inner two zones of the cortex are removed, a new ZF and ZR regenerate from glomerular cells attached to the capsule.

II. Immediately after hypophysectomy, the ZF and ZR begin to atrophy, whereas the ZG is unchanged because of the action of angiotensin II on this zone. 

III. The ability to secrete aldosterone and conserve Na+ is normal for some time after hypophysectomy, but in longstanding hypopituitarism, aldosterone deficiency may develop, apparently because of the absence of a pituitary factor that maintains the responsiveness of the zona glomerulosa. 

TLS Online TPP Program

#Question id: 34168

#Unit 7. System Physiology – Animal

Angiotensin II stimulates aldosterone production in the zona glomerulosa by binding to AT1 receptors. Which of the following best describes the intracellular signaling pathway and its role in aldosterone biosynthesis?

TLS Online TPP Program

#Question id: 34169

#Unit 7. System Physiology – Animal

Based on the provided graph panels (A–D), which of the following statements is INCORRECT?

TLS Online TPP Program

#Question id: 34170

#Unit 3. Fundamental Processes

What is correct about Klenow fragment

A. is a single polypeptide of 103 kD

B. larger cleavage product of DNA Pol I of 68 kD

C. It contains the polymerase activity

D. It contains the 3’-5’ exonuclease activity

E. It contains the 5’-3’ exonuclease activity

TLS Online TPP Program

#Question id: 34171

#Unit 3. Fundamental Processes

If the rate of fidelity of replication in bacteria is 10^-9/bp. How many replications it would take to make a mistake?

TLS Online TPP Program

#Question id: 34172

#Unit 3. Fundamental Processes

Frameshifts occur when an extra nucleotide is inserted or omitted. Which of sequence and property is most sensitive combination for the frameshift to occur