Normally, the FgfR3 protein (a receptor tyrosine kinase) is activated by a fibroblast growth factor and signals the chondrocytes to stop dividing and begin differentiating into cartilage. This signal is mediated by the Stat protein, which is phosphorylated by activated FgfR3 and then translocated into the nucleus. Inside the nucleus, Stat activates the genes encoding a cell cycle inhibitor, the p21 protein. The mutation in FgfR3 causes the lethal condition thanatophoric dysplasia. This condition may be achieved by:

A. Mutations in the extracellular domain of the FgfR3 protein

B. Mutations in the tyrosine kinase intracellular domain of the FgfR3 protein

C. Mutations in the transmembrane domain of the FgfR3 protein

Which of the following is correct?

TLS Online TPP Program

#Question id: 32248

#Unit 2. Cellular Organization

The basis for different binding affinity between the KDEL receptor and the KDEL sequence in the ER & golgi is due to:

a. the lower pH in the Golgi 

b. the higher pH in the Golgi 

c. the lower pH in the ER

d. the higher pH in the ER

TLS Online TPP Program

#Question id: 33487

#Unit 2. Cellular Organization

Match the statements

A. In the fruit fly, gene sizes have a bimodal distribution

B. 

TLS Online TPP Program

#Question id: 28577

#Unit 5. Developmental Biology

Sox9-a testes forming gene specifically upregulated by combined expression of which protein?

TLS Online TPP Program

#Question id: 23050

#Unit 12. Applied Biology

What does physical method of treatment of contaminated materials include?

TLS Online TPP Program

#Question id: 14731

#Unit 6. System Physiology – Plant

Crop Yields can be Improved by addition of fertilizers, Most chemical fertilizers contain inorganic salts of the macronutrients nitrogen, phosphorus, and potassium, Fertilizers that contain only one of these three nutrients are termed