Given below are some of the statements regarding toll signalling pathway in drosophila.

A. Dorsal protein is a transcription factor with homology to the Rel/nuclear factor kappa B (NFκB) family of vertebrate transcription factors, which are involved in regulation of gene expression in vertebrate immune responses.

B. Toll signalling pathway is also used in the adult fly in defense against infection.

C. In the Drosophila embryonic Toll pathway Dorsal is held inactive in the nucleus by the protein Cactus.

D. The ligand for Toll is a fragment of the protein Easter, which is generated in the ventral vitelline space by the protease Spatzle.

E. When Toll is activated by binding the Spätzle fragment, its cytoplasmic domain binds a complex of the adaptor proteins dMyD88 and Tube. Tube interacts with, and activates, the protein kinase Pelle.

F. Activation of Pelle leads to the dephosphorylation of Cactus. This releases Dorsal, which is then free to enter a nucleus.

Choose the most appropriate combination of correct statements:

#Question id: 3361

#Unit 11. Evolution and Behavior

In a population 16% individual affected with autosomal recessive diseased. how many are expected to be normal phenotype if population size is 250 ?

#Question id: 3362

#Unit 11. Evolution and Behavior

The Hardy-Wienberg principle comes from considering what happens when Medelian genes act on population. The model predicts that there will be no change in allele frequencies when

#Question id: 3363

#Unit 11. Evolution and Behavior

An autosomal recessive condition affects 1 newborn in 100 in a random mating population without any disruptive acting force. What is the approximate expected frequency of carriers in this population?

#Question id: 3364

#Unit 11. Evolution and Behavior

Which of the following equations represents the corresponding equilibrium for a locus with three alleles p, q and r of diploid individuals? (P, Q and R represent the frequencies of p, q and r, respectively)

#Question id: 3365

#Unit 11. Evolution and Behavior

Consider a population of 10,000 individuals, of which 2500 are homozygotes (PP) and 3000 are heterozygotes (Pp) genotype. The frequency of allele p in the population is

#Question id: 3366

#Unit 11. Evolution and Behavior

Red-Green color blindness is an X-linked recessive disorder. In a population which is in the Hardy-  Weinberg equilibrium, the incidence of occurrence of this in males is 2:2000. What will be the expected incidence of affected homozygous females?