TLS Online TPP Program

#Question id: 7197


Following statements are regarding to PAR proteins and the establishment of polarity during early development in nematodes.

A. The internal cytoplasm contains PAR-3, PAR-6, and PKC-3, and the cortical cytoplasm contains PAR-2 and PAR-1.

B. PAR-3 and PAR-6, interacting with the protein kinase PKC-3 are uniformly distributed in the cortical cytoplasm. PKC-3 restricts PAR-1 and PAR-2 to the internal cytoplasm by phosphorylating them.

C. Once PAR-1 is in the cortical cytoplasm, it phosphorylates PAR-3, causing PAR-3 (and its binding partner, PKC-3) to leave the cortex.

D. During first cleavage, the metaphase plate is closer to the posterior, and the fertilized egg is divided into two cells, one having the anterior PARs (PAR-1 and PAR-2) and one having the posterior PARs (PAR-3 and PAR-6).

Which of the following statements are correct?

#Unit 5. Developmental Biology
  1. A and B
  2. B and C
  3. C and D
  4. A, B and C