TLS Online TPP Program

#Question id: 7200


Following statements are regarding to Reaction-diffusion mechanism for proximal-distal limb specification. Which of the following statement is incorrect?

#Unit 5. Developmental Biology
  1. In the inhibitory domain immediately outside the AER, cells are kept dividing by FGFs and Wnts and are prevented from forming cartilage.
  2. In the active domain, each cell secretes but can not respond to activating paracrine factors of the TGF-β family (TGF-β, BMPs, activin) and cell adhesion factors such as galectin-1. These factors stimulate their own synthesis as well as that of the extracellular matrix and cell adhesion proteins that promote aggregation.
  3. The activating cells also stimulate the synthesis of diffusible inhibitors of aggregation (including Noggin and galectin-8), preventing cell adhesion in neighboring regions.

  4. A third domain, the “frozen zone” well beyond the influence of the AER, contains the formed cartilage primordia of the skeleton at proximal regions of the developing limb.