Which of the following statement justified that the PMZ in chick is functionally equivalent to the amphibian Nieuwkoop center?

A. The posterior marginal zone produces Wnt8c and that, the PMZ cells secrete Vg1, a member of the TGF-β family.

B. PMZ cells capable of inducing the accumulation of β-catenin

C. PMZ cells secretes BMP, a member of the TGF-β family.

D. PMZ secretes its own Nodal antagonist—the Lefty protein.

Which of the following combination is correct?

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#Question id: 861

#Unit 1. Molecules and their Interaction Relevant to Biology

Alexander Varshavsky discovered, the half-lives of many cytoplasmic proteins vary with the identities of their N-terminal residues via the so-called N-end rule:-

A. Destabilizing N-terminal residues Asp, Arg, Leu, Lys, and Phe have half-lives of	i. Only 2 to 3 minutes,
B. Stabilizing N-terminal residues Ala, Gly, Met, Ser, Thr, and Val have half-lives of	ii. >10 hours in prokaryotes iii. >20 hours in eukaryotes.

TLS Online TPP Program

#Question id: 862

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the following

lysosomal protein degradation pathways	Found in
1. Nonselective	a-well-nourished cells	i-containing the pentapeptide Lys-Phe-Glu-Arg-Gln
2- Selective	b-starving cells

TLS Online TPP Program

#Question id: 863

#Unit 1. Molecules and their Interaction Relevant to Biology

Ubiquitinated proteins are proteolytically degraded in an ATP-dependent process mediated by a large (∼2500 kD, 26S) multiprotein complex named the 26S proteasome;

TLS Online TPP Program

#Question id: 864

#Unit 1. Molecules and their Interaction Relevant to Biology

Which one is not the appropriate function of Heat Shock Proteins;

TLS Online TPP Program

#Question id: 865

#Unit 1. Molecules and their Interaction Relevant to Biology

In autophagy, the endoplasmic reticulum (ER) first gives rise to a cup-shaped, membranous cisterna called the______

TLS Online TPP Program

#Question id: 866

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is known as Sanger’s reagent