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TLS Online TPP Program

#Question id: 7244

Following statements are regarding to the evolutionary conservation of homeotic gene organization and transcriptional expression in fruit flies and mice.

A. In fruit flies and mice genes with similar structures occupy the same relative positions on each of the four chromosomes, and paralogous gene groups display similar expression patterns.

B. Hom-C cluster on Drosophila chromosome 3 and the four Hox gene clusters in the mouse genome are similar and evolutionary conserved.

C. Those mammalian genes homologous to the Drosophila labial, proboscipedia, and deformed genes are expressed anteriorly and early, whereas those genes homologous to the Drosophila AbdB gene are expressed posteriorly and later.

D. In fruit flies and mice genes are orthologous Hox gene groups.

E. Those mammalian genes homologous to the Drosophila labial, proboscipedia, and deformed genes are expressed posteriorly and later, whereas those genes homologous to the Drosophila AbdB gene are expressed anteriorly and early.

Which of the following combination is correct?

#Unit 5. Developmental Biology
  1. A, B and C
  2. A, C and E
  3. C and D only
  4. A and B only
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TLS Online TPP Program

#Question id: 13155

#Unit 2. Cellular Organization

Lysozyme is an enzyme that destroys bacterial cell walls. It does so by hydrolyzing the β(1→4) glycosidic linkages from N- acetylmuramic acid (NAM or MurNAc) to N- acetylglucosamine (NAG or GlcNAc) in cell wall peptidoglycans. The only functional groups in the immediate vicinity of lysozyme’s reactive center that have the required catalytic properties are the side chains of Glu 35 and Asp 52.
a- Glu perform reaction in its protonated state and Asp perform reaction in its deprotonated state. 
b- Glu perform reaction in its deprotonated state and Asp perform reaction in its protonated state. 
c- both in its protonated form
d- both in its deprotonated form 
Choose the correct option?
TLS Online TPP Program

#Question id: 13156

#Unit 2. Cellular Organization

Tay sach;s disease are caused when which enzyme is mutated or non-functional?
TLS Online TPP Program

#Question id: 13157

#Unit 2. Cellular Organization

Following are the some statement . Choose the correct one?
a. Primary Lysosomes are also called storage granules, protolysosomes or virgin lysosomes. Primary lysosomes are newly formed organelles bounded by a single membrane and typically having a diameter of 100 nm. They contain the degradative enzymes which  participate in digestive process. 
b. Heterophagosomes are also called heterophagic vacuoles, heterolysosomes or phagolysosomes. Heterophagosomes are formed by the fusion of primary lysosomes with cytoplasmic vacuoles containing extracellular substances brought into the cell by any of a variety of endocytic processes.
c. Autophagosomes are able to digest intracellular structures including mitochondria, ribosomes, peroxisomes and glycogen granules. 
TLS Online TPP Program

#Question id: 13158

#Unit 2. Cellular Organization

In which process, protein are first encapsulated in a membrane, then the contents of the resulting vesicle are degraded after the vesicle docks with a cytosolic lysosome.
TLS Online TPP Program

#Question id: 13159

#Unit 4. Cell Communication and Cell Signaling

How signaling is involved in ensuring that yeast cells fuse only with cells of the opposite mating type?
TLS Online TPP Program

#Question id: 13160

#Unit 4. Cell Communication and Cell Signaling

According to the Switching mechanism, monomeric G proteins exist in two states. Match the following states (Column I) with correct mechanism (Column II).

Column I

Column II

A. “ON” state 

i. switch I and switch II, are bound to the terminal γ phosphate of GTP through interactions with the backbone amide groups of conserved threonine and glycine residues.

B. “OFF” state

ii. GTPase-activating proteins

 

iii. guanine nucleotide exchange factor

 

iv. Due to the removal of the γ phosphate by GTPase-catalyzed hydrolysis causes switch I and switch II to relax into a different conformation