#Question id: 7261

The Turing model provides a framework for limb development. Following statements are regarding to this model:

A. In Turing’s model, morphogen A promotes the production of more morphogen A (autoactivation) as well as production of morphogen I. Morphogen I, however, inhibits the production of morphogen A (lateral inhibition).

B. In Turing’s model, morphogen A inhibits the production of more morphogen A (autoinhibition) as well as production of morphogen I. Morphogen I, however, promotes the production of morphogen A (lateral activation).

C. In Turing’s model, the reaction-diffusion dynamics can tell us how the limb bud acquires its proximal- distal polarity as well as how the number of digits is regulated at the distal tip of the limb.

D. The reaction-diffusion system has been proposed to be sufficient for establishing patterns of precartilage and noncartilage tissues.

E. According to this model, along the proximal-distal axis the AER dividing into two domains 1-the inhibitory domain 2-the active domain.

F. According to this model, along the proximal-distal axis the AER dividing into three domains 1-the inhibitory domain 2-the active domain 3-frozen domain.

Which of the following combinations are incorrect?