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TLS Online TPP Program

#Question id: 7273

Hox9 and Hox10 paralogues specify the stylopod, Hox11 paralogues specify the zeugopod, and Hox12 and Hox13 paralogues specify the autopod. This scenario has been confirmed by numerous experiments.

Which of the following experiment correctly describe this scenario?

#Unit 5. Developmental Biology
  1. If knocked out all six alleles of the three Hox10 paralogues (Hox10aaccdd) in mouse embryos, the resulting mice not only had severe axial skeletal defects, they also had no femur or patella they did have humerus.
  2. When all six alleles of the three Hox11 paralogues were knocked out, the resulting hindlimbs had tibias-fibulas but neither femur nor humerus.
  3. knocking out all the paralogous Hoxa9 and Hoxd12 loci resulted in loss of the autopod.
  4. If knocked out all six alleles of the three Hox10 and Hox11 paralogues (Hox10aaccdd) in mouse embryos, the resulting mice have no limb.
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TLS Online TPP Program

#Question id: 33156

#Unit 2. Cellular Organization

Which of the following statement is not correct  regarding Sequential activation of the APC/C by Cdc20 and Cdh1?
TLS Online TPP Program

#Question id: 33227

#Unit 1. Molecules and their Interaction Relevant to Biology

An uncatalyzed keto– enol tautomerization reaction occurs quite slowly as a result of the high free energy of its carbanion-like transition state called as
TLS Online TPP Program

#Question id: 33228

#Unit 1. Molecules and their Interaction Relevant to Biology

If velocity of the reaction is increased by proton abstraction by a species, mechanism is called as
TLS Online TPP Program

#Question id: 33229

#Unit 1. Molecules and their Interaction Relevant to Biology

The effects of pH on enzymes depends on a combination of factors: 
(a) Most enzymes are active within only a narrow pH range, typically 5 to 9. 
(b) the ionization states of the amino acid residues involved in the catalytic activity of the enzyme
(c) the variation of protein structure (usually significant only at extremes of pH).
Which of the above is correct
TLS Online TPP Program

#Question id: 33230

#Unit 1. Molecules and their Interaction Relevant to Biology

The pH dependence of the rate of the reaction catalyzed by fumarase produces the following curve. Which amino acid/s likely to be present in the active site
TLS Online TPP Program

#Question id: 33231

#Unit 1. Molecules and their Interaction Relevant to Biology

Which character makes concerted acid–base catalysis a common enzymatic mechanism?