Cellular senescence may have evolved to protect organisms against cancer. Instead of dividing out of control, the cells die. Cellular senescence appears to be regulated by several tumor suppressor genes, especially p53.what is the most appropriate reason behind this,

1) Transcription factor p53 is thought to suppress tumorigenesis by causing cell arrest and senescence in response to short telomeres, DNA damage, and viral or external signals to divide

2) This factor can stop the cell cycle, cause cellular senescence in rapidly dividing cells, instruct genes to initiate cellular apoptosis, and activate DNA repair enzymes.

3) Induction of apoptosis or cellular senescence by p53 always beneficial.

TLS Online TPP Program

#Question id: 28668

#Unit 2. Cellular Organization

In Yeast cells with a defective wee1+ gene activate mitotic CDKs prematurely and cause__

TLS Online TPP Program

#Question id: 28669

#Unit 2. Cellular Organization

Fission yeast cells carrying a CDK1 mutation in which the tyrosine-15 residue is replaced by phenylalanine, what will cause from this mutation?

a) Shows larger than normal cells

b) Shows smaller than normal cells

c) allows the phosphorylation of phenylalanine and normal cell activation are seen

d) premature mitotic CDK activation and entry into mitosis

TLS Online TPP Program

#Question id: 28670

#Unit 2. Cellular Organization

In fission yeast cells carrying a CDK1 mutation in which the tyrosine-15 residue is replaced by other amino acid which is?

TLS Online TPP Program

#Question id: 28671

#Unit 2. Cellular Organization

 In which of the following condition premature mitotic CDK activation and premature entry into mitosis are seen? 

a) during the activity of dual-specificity phosphatases

b) during replacing the tyrosine-15 residue from phenylalanine

c) defective wee1+ gene

TLS Online TPP Program

#Question id: 28672

#Unit 2. Cellular Organization

Which proteins is involved to inhibit Cdc25 phosphatase and hold it into inactive condition

TLS Online TPP Program

#Question id: 28673

#Unit 2. Cellular Organization

Which protein activity involve to facilitate the activating an initial small pool of cyclin B/1 at the centrosome and also facilitate centrosome Maturation?