#Question id: 7083
#Unit 5. Developmental Biology
During development in avian embryo, the sheet of cells that grows anteriorly from Koller’s sickle combines with the primary hypoblast to form the complete hypoblast layer, also called the:
#Question id: 15993
#Unit 12. Applied Biology
#Question id: 1143
#Unit 4. Cell Communication and Cell Signaling
In trimeric G proteins, GTP binds to:
#Question id: 12635
#Unit 6. System Physiology – Plant
#Question id: 7173
#Unit 5. Developmental Biology
Normally, the FgfR3 protein (a receptor tyrosine kinase) is activated by a fibroblast growth factor and signals the chondrocytes to stop dividing and begin differentiating into cartilage. This signal is mediated by the Stat protein, which is phosphorylated by activated FgfR3 and then translocated into the nucleus. Inside the nucleus, Stat activates the genes encoding a cell cycle inhibitor, the p21 protein. The mutation in FgfR3 causes the lethal condition thanatophoric dysplasia. This condition may be achieved by:
A. Mutations in the extracellular domain of the FgfR3 protein
B. Mutations in the tyrosine kinase intracellular domain of the FgfR3 protein
C. Mutations in the transmembrane domain of the FgfR3 protein
Which of the following is correct?