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TLS Online TPP Program

#Question id: 10460

CCT overexpression mutant shows____

#Unit 6. System Physiology – Plant
  1. CCT overexpression mutant lack the sequester binding site with the COP1/SPA1, therby no longer ability to prevent degradation of HY5
  2. The CCT overexpression mutant shows different responses in the light as well as in the dark
  3. CCT overexpression donot have the N-terminus, CCT region can’t adopt an active conformation and donot allows the binding with COP1/SPA1, thereby donot allows the degradation of HY5 protein
  4. In the absence of the photosensory N terminus as in the truncation mutant , the CCT region can adopt an active conformation that sequesters COP1/ SPA1 in the absence of light, thereby promoting an increase in HY5 protein levels and transcription of key morphogenic genes
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TLS Online TPP Program

#Question id: 15831

#Unit 8. Inheritance Biology

Your friends Ben and Jane are contemplating having children and seek your genetic counsel. Ben and Jane are unrelated, but both have younger brothers with the same, extremely rare genetic trait. (In fact, Ben and Jane met at a support group meeting for children and families of children with this rare disorder.) Ben’s parents and Jane’s parents are all unaffected.        
 Assume that the trait is X-linked recessive with complete penetrance. What is the probability that Ben and Jane’s first child will be affected? What is the probability that the first child will be a carrier? 
TLS Online TPP Program

#Question id: 15832

#Unit 8. Inheritance Biology

Your friends Ben and Jane are contemplating having children and seek your genetic counsel. Ben and Jane are unrelated, but both have younger brothers with the same, extremely rare genetic trait. (In fact, Ben and Jane met at a support group meeting for children and families of children with this rare disorder.) Ben’s parents and Jane’s parents are all unaffected.        
 Assume that the trait is autosomal dominant with 80% penetrance in heterozygotes and 100% penetrance in homozygotes. What is the probability that Ben and Jane’s first child will be affected? 
TLS Online TPP Program

#Question id: 15833

#Unit 8. Inheritance Biology

Your friends Ben and Jane are contemplating having children and seek your genetic counsel. Ben and Jane are unrelated, but both have younger brothers with the same, extremely rare genetic trait. (In fact, Ben and Jane met at a support group meeting for children and families of children with this rare disorder.) Ben’s parents and Jane’s parents are all unaffected.          
Assume that the trait is autosomal dominant with 80% penetrance in heterozygotes and 100% penetrance in homozygotes. If not affected, what is the probability that the child is a carrier?
TLS Online TPP Program

#Question id: 15834

#Unit 8. Inheritance Biology

You are interested in a new type of autosomal dominant mutation that gives purple eyes in Drosophila. You have a true-breeding purple-eyed line carrying a mutation that you call pr-1. You have isolated a second purple-eyed mutation that you call pr-2, which you have established in a true-breeding line that also carries a recessive marker st, which gives stubby legs. You cross a fly from the pr-1 line to a fly from the st, pr-2 line producing F1 females which you then cross to males from a true breeding st line (normal eyes). From this cross, 1000 progeny flies can be categorized into four different phenotypic classes:
                             
Normally, 3-factor crosses give eight different phenotypic classes, why does this particular cross give only four?
TLS Online TPP Program

#Question id: 15835

#Unit 8. Inheritance Biology

You are interested in a new type of autosomal dominant mutation that gives purple eyes in Drosophila. You have a true-breeding purple-eyed line carrying a mutation that you call pr-1. You have isolated a second purple-eyed mutation that you call pr-2, which you have established in a true-breeding line that also carries a recessive marker st, which gives stubby legs. You cross a fly from the pr-1 line to a fly from the st, pr-2 line producing F1 females which you then cross to males from a true breeding st line (normal eyes). From this cross, 1000 progeny flies can be categorized into four different phenotypic classes:
                       
What is the distance between pr-1 and pr-2 in cM?
TLS Online TPP Program

#Question id: 15836

#Unit 8. Inheritance Biology

You are interested in a new type of autosomal dominant mutation that gives purple eyes in Drosophila. You have a true-breeding purple-eyed line carrying a mutation that you call pr-1. You have isolated a second purple-eyed mutation that you call pr-2, which you have established in a true-breeding line that also carries a recessive marker st, which gives stubby legs. You cross a fly from the pr-1 line to a fly from the st, pr-2 line producing F1 females which you then cross to males from a true breeding st line (normal eyes). From this cross, 1000 progeny flies can be categorized into four different phenotypic classes:
                   
What is the phenotype of a pr-1 pr-2 double mutant?