With respect to microRNAs, which, if any, of the following statements, is FALSE?)

A. MicroRNA genes often occur in gene clusters within introns of protein-coding genes and are usually transcribed by RNA polymerase II.

B. Like an mRNA a miRNA is initially produced as a larger precursor RNA that, like the great majority of mRNAs, usually has a 5’ cap and a poly(A) tail.

C. MicroRNAs are produced by germ-line cells only.

D. A miRNA is initially produced as a duplex RNA but in order to work it needs to be converted into a single-strand RNA.

E. MicroRNAs usually work as transcription factors.

TLS Online TPP Program

#Question id: 2249

#Unit 2. Cellular Organization

In intestinal lumen epithelial cells, which of the following occurs by passive transport?

a. import of Na+ on the apical side    

b. export of Na+ on the basal side

c. import of glucose on the apical side           

d. export of glucose on the basal side

TLS Online TPP Program

#Question id: 2250

#Unit 2. Cellular Organization

Which of the following is true about cystic fibrosis?

TLS Online TPP Program

#Question id: 2251

#Unit 2. Cellular Organization

Differences between cotransport and active ion transport include

TLS Online TPP Program

#Question id: 2252

#Unit 2. Cellular Organization

The generation and maintenance of a membrane electric potential requires which of the following:

a. active pumping of ions       

b. ion-specific membrane channel proteins

c. ATP                                    

d. a generally permeable membrane

TLS Online TPP Program

#Question id: 2253

#Unit 2. Cellular Organization

Match the following lipid linked proteins (column I) with their function (Column II).

Column I	Column II
A. prenylated proteins	i. These proteins are located in a number of subcellular compartments, including the cytosol, the endoplasmic reticulum, the inner face of the plasma membrane, and the nucleus.
B. fatty acylated proteins	ii. The core structure of these proteins consists of phosphatidylinositol glycosidically linked to a linear tetrasaccharide composed of three mannose residues and one glucosaminyl residue.
C. glycosylphosphatidylinositol-linked proteins	iii. The proteins that have covalently attached lipids that are built from isoprene units

TLS Online TPP Program

#Question id: 2253

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the following lipid linked proteins (column I) with their function (Column II).

Column I	Column II
A. prenylated proteins	i. These proteins are located in a number of subcellular compartments, including the cytosol, the endoplasmic reticulum, the inner face of the plasma membrane, and the nucleus.
B. fatty acylated proteins	ii. The core structure of these proteins consists of phosphatidylinositol glycosidically linked to a linear tetrasaccharide composed of three mannose residues and one glucosaminyl residue.
C. glycosylphosphatidylinositol-linked proteins	iii. The proteins that have covalently attached lipids that are built from isoprene units