Following table lists the two major forms of DNA duplexes, conformation of base attached to the sugar and the nature of major and minor grooves.

DNA duplex	Properties
(A)  A form	(i) Syn conformation of the base to sugar
(B)  B form	(ii) Anti conformation of the base to sugar
	(iii) Wide major groove
	(iv) Narrow major groove
	(v) Wide minor groove
	(vi) Narrow minor groove
	(vii) C-3’ endo sugar puckering
	(viii) C-2’ endo sugar puckering

#Question id: 3805

#Unit 3. Fundamental Processes

A newly replicated DNA duplex is likely to have:

#Question id: 3806

#Unit 3. Fundamental Processes

How are damaged nucleotides recognized by DNA repair enzymes?

#Question id: 3807

#Unit 3. Fundamental Processes

If the genes from the following list were damaged, which gene would most likely be repaired first?

#Question id: 3808

#Unit 3. Fundamental Processes

Fibroblast cells from several different xeroderma pigmentosa patients were cultured, then fused in intergenic complementation studies. Which cell fusions would not result in a hybrid capable of repairing damaged DNA?

#Question id: 3809

#Unit 3. Fundamental Processes

MMR is a highly conserved biological pathway. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. Match the following

#Question id: 3810

#Unit 3. Fundamental Processes

In the diagram below, the dotted line marks the point of initiation of bidirectional replication

A. On the right side of the dotted line, leading strand synthesis occurs using the lower strand as the template.

B. On the right side of the dotted line, leading strand synthesis occurs using the upper strand as the template.

C. A ligase deficient (lig- ) mutant would affect replication of t11e upper strand on the left side of the dotted line.

D. A ligase deficient (lig- ) mutant would affect replication of the lower strand on the left side

of the dotted line_

Which one of the following options represents the combinations of the CORRECT statements?