Alexander Varshavsky discovered, the half-lives of many cytoplasmic proteins vary with the identities of their N-terminal residues via the so-called N-end rule:-

A. Destabilizing N-terminal residues Asp, Arg, Leu, Lys, and Phe have half-lives of	i. Only 2 to 3 minutes,
B. Stabilizing N-terminal residues Ala, Gly, Met, Ser, Thr, and Val have half-lives of	ii. >10 hours in prokaryotes iii. >20 hours in eukaryotes.

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#Question id: 10935

#Unit 1. Molecules and their Interaction Relevant to Biology

The pH at which imidazole of histidine ring will be protonated………….. and imine group of proline will be deprotonated…………….

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#Question id: 26455

#Unit 3. Fundamental Processes

The length of the RNA–DNA hybrid within the bubble is only of

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#Question id: 1352

#Unit 4. Cell Communication and Cell Signaling

Actin filaments are to focal adhesions as   _____   are to hemidesmosomes.

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#Question id: 15765

#Unit 5. Developmental Biology

What is symmetrical differentiation?

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#Question id: 4486

#Unit 3. Fundamental Processes

Activators can recruit factors needed for polymerase to initiate or elongate transcription. In all of these functions, the activator is merely recruiting proteins to the promoter. In bacteria, RNA polymerase is the only protein that needs to be recruited; this is not the case in eukaryotes. Indeed, in eukaryotes, a given activator might work in all three ways:

1.    Recruitment of nucleosome modifiers and remodelers	i.     “open” the promoter
2.    Recruitment of general transcription factors and mediators	ii.      That stimulate Pol II initiation and elongation
3.       Recruitment of protein complexes	iii.     To recruit PTEFb/SEC