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TLS Online TPP Program

#Question id: 12185

Mitotic CDKs affect nuclear envelope components by specific mechanism. Which of the following statement is not related to this mechanism?

#Unit 2. Cellular Organization
  1. The CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate into subcomplexes during prophase. 
  2. Phosphorylation of integral membrane proteins of the inner nuclear membrane causes depolymerization of the lamin intermediate filaments.
  3. The weakening of the associations between the inner nuclear membrane proteins and the nuclear lamina and chromatin allows sheets of inner nuclear membrane to retract into the endoplasmic reticulum, which is continuous with the outer nuclear membrane.
  4. Mitotic CDKs induce the formation of the mitotic spindle. The function of the mitotic spindle is to segregate chromosomes so that the sister chromatids separate from each other and are moved to opposite poles of the cell.
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TLS Online TPP Program

#Question id: 1396

#Unit 4. Cell Communication and Cell Signaling

Trks are:

a. endonucleases.        b. transmembrane receptors.   c. proteases.     d. protein kinases.      
TLS Online TPP Program

#Question id: 1397

#Unit 4. Cell Communication and Cell Signaling

The vertebrate equivalent of CED-9 is:
TLS Online TPP Program

#Question id: 1398

#Unit 4. Cell Communication and Cell Signaling

Which of the following properties is (are) characteristic of a benign tumor?

a. well differentiated              b. localized to tissue of origin             c. metastatic               

d. promotes angiogenesis        e. surrounded by a fibrous capsule
TLS Online TPP Program

#Question id: 1399

#Unit 4. Cell Communication and Cell Signaling

Loss-of-function mutations in which of the following genes typifies colorectal carcinomas?

a. myc              b. K-ras                       c. p53              d. APC
TLS Online TPP Program

#Question id: 1400

#Unit 4. Cell Communication and Cell Signaling

Which property is shared by malignant tumor cells and transformed cells in culture?

a. reduced growth factor requirement                        b. attachment-dependent growth

c. loss of actin microfilaments                                    d. altered morphology
TLS Online TPP Program

#Question id: 1401

#Unit 4. Cell Communication and Cell Signaling

Which of the following are proto-oncogenes?

a. fos               b. myc             c. p53              d. ras               e. Rb