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TLS Online TPP Program

#Question id: 15302

#Unit 5. Developmental Biology

FOXP1 is a transcription factor which stimulate the production of Oct4 and Nanog and establish pluripotency. Which of the following statements are correct regarding to the mechanism of alternative splicing of FOXP1. 

A. There are two isoforms of the FoxP1 protein, One is the product of an mRNA spliced to include a particular exon, 18b, while the other splicing variant carries exon 18a.

B. When alternative splicing generates a form including exon 18b in place of 18a, the resulting isoform (FOXP1-ES) binds to a different DNA sequence and thus controls expression of a different set of genes.

C. The protein encoded by the exon 18b– carrying mRNA is called FOXP1-ES it fails to stimulate expression of OCT4 and NANOG and instead actives genes that promote differentiation. 

D. The exon 18a– containing form encodes FOXP1 itself, and this has the opposite effect: this activates genes that promote dedifferentiation, and thus stimulates iPS cell formation.

TLS Online TPP Program

#Question id: 15391

#Unit 5. Developmental Biology

In the initiation of the vertebrate eyes, paired regions of the brain bulge out and approach the anterior region of -------germ layer:

TLS Online TPP Program

#Question id: 15392

#Unit 5. Developmental Biology

If an optic vesicle from a Xenopus laevis embryo is placed underneath head ectoderm in a different part of the head from where the frog’s optic vesicle normally occurs then what happens?

TLS Online TPP Program

#Question id: 15393

#Unit 5. Developmental Biology

First inducers (in early gastrula stages) of the lens may be:

TLS Online TPP Program

#Question id: 15394

#Unit 5. Developmental Biology

The elongation and curvature of the lens fibers control by:

TLS Online TPP Program

#Question id: 15395

#Unit 5. Developmental Biology

Which of the following promote the synthesis of the Paired box 6 (Pax6) transcription factor in the anterior ectoderm?