Following statements are regarding to Kinetochore-microtubule interaction in S. cerevisiae.

A. In the simple kinetochore of S. cerevisiae, a protein complex called CBF3 associates with specialized, centromere-specific form of histone H3, called CENP-A.

B. The Ndc80 complexes initially make lateral interactions with a spindle microtubule and subsequently interact with a Dam1 complex, which forms a ring around the end of the microtubule. This interaction results in an end-on attachment of the centromere to the

spindle microtubule.

C. Microtubules that “capture” kinetochores are selectively stabilized by a reduction in the rate of catastrophes, which increases the chance that the attachment will persist.

D. With the two kinetochores attached to opposite poles, the duplicated chromosome is now under tension, being pulled in both directions by the one sets of kinetochore microtubules.

Which of the following combinations is correct?

#Question id: 401

#Unit 1. Structure and Function of Biomolecules

.Which of the following graphs describes the relationship between [H3O+] and pH?

#Question id: 402

#Unit 1. Structure and Function of Biomolecules

If the DG'° of the reaction A -> B is –40 kJ/mol, under standard conditions the reaction:

#Question id: 403

#Unit 1. Structure and Function of Biomolecules

For the reaction A -> B, DG'° = –60 kJ/mol.  The reaction is started with 10 mmol of A; no B is initially present.  After 24 hours, analysis reveals the presence of 2 mmol of B, 8 mmol of A. Which is the most likely explanation?

#Question id: 404

#Unit 1. Structure and Function of Biomolecules

When a mixture of 3-phosphoglycerate and 2-phosphoglycerate is incubated at 25 °C with phosphoglycerate mutase until equilibrium is reached, the final mixture contains six times as much 2-phosphoglycerate as 3-phosphoglycerate.  Which one of the following statements is most nearly correct, when applied to the reaction as written?  (R = 8.315 J/mol·K; T = 298 K)  3-Phosphoglycerate -> 2-phosphoglycerate

#Question id: 405

#Unit 1. Structure and Function of Biomolecules

When a mixture of glucose 6-phosphate and fructose 6-phosphate is incubated with the enzyme phosphohexose isomerase (which catalyzes the interconversion of these two compounds) until equilibrium is reached, the final mixture contains twice as much glucose 6-phosphate as fructose 6-phosphate.  Which one of the following statements is best applied to this reaction outlined below? (R = 8.315 J/mol·K; T = 298 K) Glucose 6-phosphate -> fructose 6-phosphate

#Question id: 406

#Unit 1. Structure and Function of Biomolecules

Hydrolysis of 1 M glucose 6-phosphate catalyzed by glucose 6-phosphatase is 99% complete at equilibrium (i.e., only 1% of the substrate remains). Which of the following statements is most nearly correct? (R = 8.315 J/mol·K; T = 298 K)