TLS Online TPP Program

#Question id: 12836


The final layer of control that is critical in the regulation of CDKs is a family of proteins known as CDK inhibitors, or CKIs, which bind directly to the cyclin-CDK complex and inhibit its activity. Which of the following function not done by CKIs?

#Unit 2. Cellular Organization
  1. Binding of INK4s to CDK4 and CDK6 blocks their interaction with cyclin D and hence their protein kinase activity. 
  2. p27 prevents the premature activation of S phase CDKs during G1.
  3. p21CIP plays an important role in the response of metazoan cells to DNA damage by inhibiting G1/S phase CDKs and S phase CDKs, and thereby blocking entry into or passage through S phase.
  4. During ongoing DNA replication and in response to replication stress (slow DNA replication fork movement or DNA replication fork collapse), the ATR-Chk1 protein kinase cascade phosphorylates and inactivates Cdc25C, thereby preventing the activation of mitotic CDKs and inhibiting entry into mitosis.
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TLS Online TPP Program

#Question id: 1970

#Unit 4. Cell Communication and Cell Signaling

What are antigens?

TLS Online TPP Program

#Question id: 5052

#Unit 5. Developmental Biology

cell populations within each germ layer expand and differentiate, resident stem cells are maintained within these developing tissues and function to generate cell types with restricted specificity for the tissue in which they reside. these stem cells are-

TLS Online TPP Program

#Question id: 1385

#Unit 4. Cell Communication and Cell Signaling

The ability of a population of fibroblasts to migrate along the surface of a tissue culture dish depends on adhesion between the cell surface and the extracellular matrix molecules coating the dish. The dish is coated with laminin, and the only cell-surface protein capable of binding laminin is a cell-adhesion protein called an integrin. Integrins are integral plasma-membrane proteins that function as heterodimers. Under these conditions the rate at which a fibroblast can migrate along the laminin coated culture dish is proportional to the strength of adhesion between the cell and the laminin substrate. The table below lists the rate of cell migration observed for fibroblasts genetically engineered to generate the indicated phenotypes.

 Which of the following is the most likely explanation for failure of overexpression of the integrin alpha subunit to alter the rate of fibroblast migration?

TLS Online TPP Program

#Question id: 3347

#Unit 11. Evolution and Behavior

Which one of the following statements is NOT TRUE about homologous organ?

TLS Online TPP Program

#Question id: 7577

#General Aptitude

Two cyclists do the same journey by travelling at 9 km/hr and 10 km/hr respectively. Find the distance travelled when one takes 32 minutes longer than the other.