TLS Online TPP Program

#Question id: 12954


A 55-year-old male patient with hypertension has had his blood pressure reasonably well controlled by administration of a thiazide diuretic. During his last visit (6 months ago) his blood pressure was 130/75 mm Hg and his serum creatinine was 1 mg/100 ml. He has been exercising regularly for the past 2 years, but recently has complained of knee pain and began taking large amounts of a nonsteroidal anti-inflammatory drug. When he arrives at your office, his blood pressure is 155/85 and his serum creatinine is now 2.5 mg/100 ml. Which of the following best explains his increased serum creatinine?

#Unit 7. System Physiology – Animal
  1. Increased efferent arteriolar resistance that reduced GFR
  2. Increased afferent arteriolar resistance that reduced GFR
  3. Increased glomerular capillary filtration coefficient that reduced GFR
  4. Increased angiotensin II formation that decreased GFR