Correct statements about RAPD’s

A. RAPD polymorphism is detected by using oligonucleotides usually more than 10 bases long of random sequences as primers in a reaction.

B. In a strain which has in genomic DNA sequences complementary to the primer oligonucleotide, PCR products will be detected in the gel,

C. Typical RAPD markers show limited variation between parents, especially in naturally inbreeding species.

D. RAPDs are more sensitive than RFLPs to experimental conditions making them more difficult to be consistent and reproducible.

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#Question id: 18083

#Unit 8. Inheritance Biology

The interaction of selection and inbreeding in determining the incidence of autosomal recessive diseases. Consider a gene in which recessive mutations occur at a rate of 10^-5. Assume a selective disadvantage S of 0.4 in homozygotes for the recessive allele. Would q be expected to rise, fall, or remain unchanged during the first 10 generations after the cessation of inbreeding, Briefly justify your answer. What numerical value would q approach after thousands of generations with no inbreeding?

TLS Online TPP Program

#Question id: 18227

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal dominant disease. You are focused on two SSR markers that may be linked to each other and to the disease. Here is a family in which some individuals are affected:

 

Calculate LOD scores for linkage at θ = 0.1 between the disease and SSR62

TLS Online TPP Program

#Question id: 18228

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal dominant disease. You are focused on two SSR markers that may be linked to each other and to the disease. Here is a family in which some individuals are affected:

 

Calculate LOD scores for linkage at θ = 0.1 between the disease and SSR93?

TLS Online TPP Program

#Question id: 18229

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal dominant disease. You are focused on two SSR markers that may be linked to each other and to the disease. Here is a family in which some individuals are affected:

 

Calculate LOD scores for linkage at θ = 0.1 between SSR62 and SSR93

TLS Online TPP Program

#Question id: 18969

#Unit 8. Inheritance Biology

Consider the ABO “blood type” gene. This single gene has three alleles called A, B, and O. There are four resultant “blood types” (phenotypic classes), as follows:C

                               

Assume Hardy-Weinberg equilibrium. In Norway, the frequencies of the A and B alleles are 0.26 and 0.07, respectively. What is the frequencies of these six genotypes (AA, AO, BB, BO, AB, and OO);

TLS Online TPP Program

#Question id: 18970

#Unit 8. Inheritance Biology

Consider the ABO “blood type” gene. This single gene has three alleles called A, B, and O. There are four resultant “blood types” (phenotypic classes), as follows:

                                     

Assume Hardy-Weinberg equilibrium,  the frequencies of the A and B alleles are 0.26 and 0.07, respectively. What is the frequencies of the four blood types such as A, B, AB  and O in Norway;