TLS Online TPP Program

#Question id: 13163


Following statements are regarding to the interaction between β2-adrenergic receptor and G- protein.

#Unit 4. Cell Communication and Cell Signaling
  1. Binding of ligand to the receptor induces major conformational changes in which there are substantial movements of transmembrane helices 5 and 6 and changes in the structure of the C3 loop; together, these changes create a surface that can bind to a segment of the Gα subunit and when unbound by ligand, the receptor has no surface that is complementary to the G protein and thus cannot bind to it.
  2. Binding of ligand to the receptor induces major conformational changes in which there are substantial movements of transmembrane helices 1 and 4 and changes in the structure of the C3 loop; together, these changes create a surface that can bind to a segment of the Gα subunit and when unbound by ligand, the receptor has no surface that is complementary to the G protein and thus cannot bind to it.
  3. Binding of ligand to the receptor induces major conformational changes in which there are substantial movements of transmembrane helices 5 and 6 and changes in the structure of the C3 loop; together, these changes have no surface that can’t bind to a segment of the Gα subunit and when unbound by ligand, the receptor creates a surface that is complementary to the G protein and thus can bind to it.
  4. Binding of ligand to the receptor induces major conformational changes in which there are substantial movements of transmembrane helices 3, 5, 6 and 7 and changes in the structure of the E2 loop; together, these changes create a surface that can bind to a segment of the Gα subunit and when unbound by ligand, the receptor has no surface that is complementary to the G protein and thus cannot bind to it.