A mutated E. coli cell carries out and completes DNA replication, but the lagging strands are found to contain more errors than normal. These errors are not found evenly distributed throughout the lagging strands, but are found in clusters. Which enzymatic activity is missing from this cell?

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#Question id: 12487

#Part-A Aptitude & General Biotechnology

Neurofibromatosis type 1 is one of the most common autosomal dominant disorders. A woman with neurofibromatosis type 1 has an unaffected partner. Which of the following is correct regarding their children?

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#Question id: 12487

#Part-B Specialized Branches in Biotechnology

Neurofibromatosis type 1 is one of the most common autosomal dominant disorders. A woman with neurofibromatosis type 1 has an unaffected partner. Which of the following is correct regarding their children?

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#Question id: 12488

#Part-A Aptitude & General Biotechnology

Retinoblastoma usually occurs as a sporadic event but in around 10% of cases there is a positive family history due to autosomal dominant inheritance. In these families the penetrance is approximately 80% (= 0.8). A woman with retinoblastoma, whose father and grandfather were also affected, has an unaffected partner with no relevant family history. Which of the following is correct regarding their children?

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#Question id: 12489

#Part-A Aptitude & General Biotechnology

Achondroplasia shows autosomal dominant inheritance with complete penetrance. A man with achondroplasia has an unaffected partner of normal height. Their first two children are not affected. Which of the following is correct?

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#Question id: 12490

#Part-A Aptitude & General Biotechnology

Tay-Sachs disease shows autosomal recessive inheritance. Parents of a newly diagnosed affected child are referred for genetic counselling. It would be correct to tell them that:

TLS Online TPP Program

#Question id: 12490

#Part-B Specialized Branches in Biotechnology

Tay-Sachs disease shows autosomal recessive inheritance. Parents of a newly diagnosed affected child are referred for genetic counselling. It would be correct to tell them that: