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TLS Online TPP Program

#Question id: 4372

Which statement is not true about the binding of TBP (TATA binding protein)?

#Part-A Aptitude & General Biotechnology

  1. The TBP subunit is only required for the initiation of transcription of class II genes.

  2. The binding of TBP to DNA distorts the DNA out of the standard B-DNA form.

  3. Contacts between TBP and DNA are mainly in the minor groove.

  4. TBP forms a saddle-shaped molecular clamp that surrounds DNA at the TATA box.

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TLS Online TPP Program

#Question id: 12493

#Part-A Aptitude & General Biotechnology

Cystic fibrosis shows autosomal recessive inheritance with an incidence of 1 in 2500. The unaffected brother of an affected girl is referred for genetic counseling. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?
TLS Online TPP Program

#Question id: 12494

#Part-A Aptitude & General Biotechnology

Hunter syndrome is a rare form of mucopolysacchararidosis that differs from all other forms in that it shows X-linked recessive inheritance. A woman with two affected brothers is referred for genetic counselling. Which of the following is correct?
TLS Online TPP Program

#Question id: 12495

#Part-A Aptitude & General Biotechnology

Haemophilia A is a severe coagulation disorder that shows X-linked recessive inheritance. Red-green colour blindness also shows X-linked recessive inheritance. A man with both haemophilia A and colour blindness is referred for genetic counseling. Assume that his partner is not a carrier of either of these conditions. Which of the following is correct?
TLS Online TPP Program

#Question id: 12496

#Part-A Aptitude & General Biotechnology

A woman who has two brothers and a maternal uncle (her mother's brother) with non-specific X-linked mental retardation is referred for genetic counselling. There are no diagnostic tests available to help determine whether or not she is a carrier. Which of the following is correct?
TLS Online TPP Program

#Question id: 12497

#Part-A Aptitude & General Biotechnology

In this pedigree A and B represent alleles at a marker locus closely linked to the disease locus. Affected individuals are shown as shaded. The disease status in III 1 is unknown. Which of the following is correct?
TLS Online TPP Program

#Question id: 12498

#Part-A Aptitude & General Biotechnology

In this pedigree II 1 is affected with an autosomal recessive disorder. The disease status for II 2 and II 3 is unknown. A and B represent alleles at a locus which is tightly linked to the disease locus with recombination fraction of 0. On the basis of the linked marker genotypes II 2 can be told that: