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#Question id: 12496


A woman who has two brothers and a maternal uncle (her mother's brother) with non-specific X-linked mental retardation is referred for genetic counselling. There are no diagnostic tests available to help determine whether or not she is a carrier. Which of the following is correct?

#Part-A Aptitude & General Biotechnology
  1. The prior probability that she is a carrier is 1 in 4.
  2. The woman already has two unaffected sons. Therefore, the probability that she is a carrier can be calculated using Bayes' theorem to be 1 in 5.
  3. This means that the probability that her next son will be affected or that her next daughter will be a carrier is 1 in 5.
  4. The probability that the maternal grandmother of this woman is a carrier is 1 in 2.
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TLS Online TPP Program

#Question id: 5708

#Part-A Aptitude & General Biotechnology

If non-disjunction occurs in meiosis I, which of the following scenario is most likely to occur?

TLS Online TPP Program

#Question id: 5713

#Part-B Specialized Branches in Biotechnology

Following some statement are correct?

A) Translocation may be associated with movement of genetic material within the same chromosome

B) A person that is heterozygous for translocation may result in non viability in their zygote

C)  A person that is heterozygous for inversion may result in non viability in their recombinant zygote

D) A person that is heterozygous for translocation and lack of crossing over within translocated area result in all viable gametes

TLS Online TPP Program

#Question id: 5715

#Part-B Specialized Branches in Biotechnology

Following some abnormality is due to Gene rearrangement on chromosome. 

A, Affecting the expression of gene

B. Disrupt the function of gene

C. Reduced recombination between gene present in inverted region

D. Cross over suppressor 

Which of the following above abnormality is may be associated with inversion?

TLS Online TPP Program

#Question id: 5716

#Part-B Specialized Branches in Biotechnology

Which of the meiotic pairing possibilities in tetraploids and their consequence is correct?

A-chromosomes pair as bivalents, segregate normally producing diploid gametes.

B- Chromosomes pair as quadrivalent, segregates normally producing tetraploid gametes.

C-Chromosome pair as Trivalents form, segregation leads to nonfunctional aneuploid gametes

 D- Chromosome pair as Trivalents form, segregation leads to producing diploid gametes

TLS Online TPP Program

#Question id: 5720

#Part-B Specialized Branches in Biotechnology

Which two of the following are the CORRECT statements ?

P. Nondisjunction in the parental meiosis is not essential to produce diploid organisms

Q. Nondisjunction in the parental meiosis is essential to produce aneuploid organisms

R. Nondisjunction in the parental meiosis is essential to produce hexaploid organism

S. Nondisjunction in the parental meiosis is essential to produce tetraploid organisms

TLS Online TPP Program

#Question id: 5721

#Part-B Specialized Branches in Biotechnology

There is paracentric inversion heterozygote ABCDEFG/ABFEDCG involved in double recombination during meiosis I within inverted region result in

A. dicentric and an acentric chromosome in meiosis I as the chiasmata get terminated.

B. appearance of deletion in both the cross over product

C. all gamete are viable

D. nonviable gametes from crossover products.

Which of the above statements are correct?