Positive Costimulatory Receptors: ICOS

ICOS binds to another member of the growing B7 family, ICOS-ligand (ICOS-L), which is also expressed on a subset of activated APCs.

ICOS plays a key role in maintaining the activity of already differentiated effector and memory T cells.

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Cdc25B is act as a starter phosphatase that initiates CDK1 activation

Cdc25C is the workhorse phosphatase that activates the vast majority of cyclin-CDK1 complexes

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Cohesins are composed of four subunits: 

Smc1, Smc3, Scc1, and Scc3

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Glycoproteins

Proteins with attached carbohydrates

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T-dependent response

Recognition of protein antigens and requires the participation of CD4 helper T cells