Binding of the extracellular TCR domain to a MHC-peptide complex triggers activation of ZAP70 protein tyrosine kinases attached to the cytosolic domains of the two adjacent ζ chains. 

TLS Online TPP Program

#Id: 8892

#Section 3: Genetics, Cellular and Molecular Biology

Amphitelic attachment, 

sister kinetochores attach to microtubules emanating from opposite spindle poles, they are stably attached

TLS Online TPP Program

#Id: 8893

#Section 3: Genetics, Cellular and Molecular Biology

Merotelic attachment 

A kinetochore can attach to microtubules emanating from both poles at the same time

TLS Online TPP Program

#Id: 8894

#Section 3: Genetics, Cellular and Molecular Biology

Syntelic attachment 

Both kinetochores of a sister chromatid pair can attach to microtubules from the same pole

TLS Online TPP Program

#Id: 8895

#Section 3: Genetics, Cellular and Molecular Biology

Monotelic attachment 

only one kinetochore can attach to microtubules

TLS Online TPP Program

#Id: 8897

#Section 3: Genetics, Cellular and Molecular Biology

Sensing mechanism used by cells to detect incorrect chromosome attachments is based on tension.

TLS Online TPP Program

#Id: 8898

#Section 3: Genetics, Cellular and Molecular Biology

If Amphitelic attachment occur  Microtubules pull kinetochores; cohesins resist this pulling force. The resulting tension leads to the outer kinetochore component Ndc80 being pulled away from the protein kinase Aurora B