TLS Online TPP Program

#Id: 8205

#Section 3: Genetics, Cellular and Molecular Biology

Membranes of late endosomes and lysosomes contain V-class proton pumps that act in concert with Cl- channels to acidify the vesicle lumen.

TLS Online TPP Program

#Id: 8204

#Section 3: Genetics, Cellular and Molecular Biology

Lysosome H+ pump are V-type ATPases and has a similar architecture to the F-type ATPases

TLS Online TPP Program

#Id: 8203

#Section 3: Genetics, Cellular and Molecular Biology

An H+ ATPase in the membrane pumps H+ into the lysosome, maintaining its lumen at an acidic pH.

TLS Online TPP Program

#Id: 8202

#Section 3: Genetics, Cellular and Molecular Biology

Most of the lysosome membrane proteins, are highly glycosylated, which helps to protect them from the lysosome proteases

TLS Online TPP Program

#Id: 8201

#Section 3: Genetics, Cellular and Molecular Biology

Lysosome an interior pH of about 4.5–5.0

TLS Online TPP Program

#Id: 8200

#Section 3: Genetics, Cellular and Molecular Biology

For optimal activity, of acid hydrolases they need to be: Activated by proteolytic cleavage Requires an acid environment.