Negatively charged amino acids have four ionisations zones

1. 1--------pK1 – charge +1

2. pK1---------pKr charge 0

3. pKr---------pK2 charge -1

4. pK2---------14 charge -2

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One individual, however, expresses only a small number of these molecules—up to six different class I molecules and 12 or more different class II molecules.

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MHC molecules in mouse

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Codominant Expression

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IFN- ¥ has been shown to induce expression of the class II transcriptional activator (CIITA).