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TLS Online TPP Program

#Id: 8062

Proline- helix, secondary structure, dihedral angles, stress, GRB2, collagen
Serine- O-linked oligosaccharides, Chymotrypsin, ATM ATR Kinases, Akt/PKB, Aurora kinases, TGF, PS, β-catenin, FOXO3a
Threonine- chiral centres, same as serine, T14

#Section 2: General Biology #Amino Acids #Part B Pointers
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TLS Online TPP Program

#Id: 7967

#Section 3: Genetics, Cellular and Molecular Biology

Hydrolysis of the bound GTP accompanies disassembly of the SRP and SRP receptor and initiates transfer of the nascent chain and ribosome to a site on the ER membrane, where translocation can take place.
TLS Online TPP Program

#Id: 7966

#Section 3: Genetics, Cellular and Molecular Biology

Binding of BiP to the luminal domain of monomeric Ire1 prevents formation of the Ire1 dimer.
TLS Online TPP Program

#Id: 7965

#Section 3: Genetics, Cellular and Molecular Biology

Unassembled or misfolded proteins in the ER are often transported back to the cytosol, where they are degraded in the ubiquitin-proteasome pathway
TLS Online TPP Program

#Id: 7964

#Section 3: Genetics, Cellular and Molecular Biology

Emphysema caused by a point mutation in -antitrypsin, which is normally secreted by hepatocytes and macrophages.
TLS Online TPP Program

#Id: 7963

#Section 3: Genetics, Cellular and Molecular Biology

A hereditary form of emphysema illustrates the detrimental effects that can result from misfolding of proteins in the ER.
TLS Online TPP Program

#Id: 7962

#Section 3: Genetics, Cellular and Molecular Biology

Hac1 activates transcription of genes encoding several protein-folding catalysts.