The amino group at C-2 bears a fatty acid in amide linkage.

The fatty acid is usually saturated or monounsaturated, with 16, 18, 22, or 24 carbon atoms.

Ceramide is the parent compound for this group.

TLS Online TPP Program

#Id: 8623

#Section 3: Genetics, Cellular and Molecular Biology

SCF and APC/C are multisubunit ubiquitin-protein ligases that belong to the RING finger family of ubiquitin-protein ligases.

TLS Online TPP Program

#Id: 8625

#Section 3: Genetics, Cellular and Molecular Biology

Human SCF complexes contain: 

Three core components - Cul1 subunit, RBX1, Skp1 

and a substrate-targeting F-box protein

TLS Online TPP Program

#Id: 8626

#Section 3: Genetics, Cellular and Molecular Biology

RBX1 is a RING finger–containing protein that binds the E2 ubiquitin-conjugating enzyme.

TLS Online TPP Program

#Id: 8627

#Section 3: Genetics, Cellular and Molecular Biology

phosphoserine/threonine-binding F-box protein is Skp2, which uses a series of leucine-rich repeats to bind to target proteins only when they are phosphorylated.

TLS Online TPP Program

#Id: 8628

#Section 3: Genetics, Cellular and Molecular Biology

APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

#Id: 8629

#Section 3: Genetics, Cellular and Molecular Biology

APC/C works with substrate-targeting factors called Cdc20 and Cdh1