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TLS Online TPP Program

#Id: 8343

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly


#Section 3: Genetics, Cellular and Molecular Biology #MICROFILAMENTS #Part B Pointers
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TLS Online TPP Program

#Id: 8655

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8656

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8846

#Section 3: Genetics, Cellular and Molecular Biology

In budding yeast CKI p27 = Sic1 in metazoans
TLS Online TPP Program

#Id: 8847

#Section 3: Genetics, Cellular and Molecular Biology

When CDK activity is low= helicases are loaded in G1
When CDK activity is high= helicases are activated in
S, G2 & M
TLS Online TPP Program

#Id: 8848

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8849

#Section 3: Genetics, Cellular and Molecular Biology

Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)