Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif, the destruction box or D-box, has the consensus sequence

RXXLX[D/E]ΦΦΦXN[N/S]

TLS Online TPP Program

#Id: 8368

#Section 3: Genetics, Cellular and Molecular Biology

Myosin V

Two heads but does not assemble into filaments

Large and processive

Function- Organelle transport

TLS Online TPP Program

#Id: 8116

#Section 2: General Biology

Fingolimod—a Sphingosine-1-P Mimic Is an Oral Drug for Multiple Sclerosis

TLS Online TPP Program

#Id: 10324

#Section 2: General Biology

PD-1 has a structure similar to CTLA-4 and when activated negatively regulates T-cell function by inducing apoptosis of activated T cells. 

TLS Online TPP Program

#Id: 8972

#Section 3: Genetics, Cellular and Molecular Biology

Gene Structure

The genes that code for many proteins are broken into pieces. These pieces—the exons—are separated by stretches of noncoding DNA—the introns

TLS Online TPP Program

#Id: 7757

#Section 2: General Biology

Molecules are groups of atoms that behave as a single unit.