CAUSES OF GENETIC DRIFT

Genetic drift in a small population over multiple generations can significantly affect the composition of a population’s gene pool. 

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#Id: 8893

#Section 3: Genetics, Cellular and Molecular Biology

Merotelic attachment 

A kinetochore can attach to microtubules emanating from both poles at the same time

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#Id: 8894

#Section 3: Genetics, Cellular and Molecular Biology

Syntelic attachment 

Both kinetochores of a sister chromatid pair can attach to microtubules from the same pole

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#Id: 8895

#Section 3: Genetics, Cellular and Molecular Biology

Monotelic attachment 

only one kinetochore can attach to microtubules

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#Id: 8897

#Section 3: Genetics, Cellular and Molecular Biology

Sensing mechanism used by cells to detect incorrect chromosome attachments is based on tension.

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#Id: 8898

#Section 3: Genetics, Cellular and Molecular Biology

If Amphitelic attachment occur  Microtubules pull kinetochores; cohesins resist this pulling force. The resulting tension leads to the outer kinetochore component Ndc80 being pulled away from the protein kinase Aurora B

TLS Online TPP Program

#Id: 8900

#Section 3: Genetics, Cellular and Molecular Biology

The Aurora protein kinase family members Aurora A and Aurora B and their associated regulatory factors sense kinetochores that are not under tension and sever these microtubule attachments