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Nonsynonymous mutations, on the other hand, alter the amino acid sequence of the protein and in many cases are detrimental to the fitness of the organism, so most of these mutations are eliminated by natural selection.

#Section 3: Genetics, Cellular and Molecular Biology #Fitness and natural Selection #Part B Pointers
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#Section 2: General Biology

Fingolimod—a Sphingosine-1-P Mimic Is an Oral Drug for Multiple Sclerosis

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#Section 2: General Biology

Excreted S1P provokes many different cell and tissue effects, among them inflammation in allergic reactions, cell proliferation, angiogenesis, malignant transformation, and movement and migration of certain cells.

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#Id: 8114

#Section 2: General Biology

Sphingosine itself can be phosphorylated to produce sphingosine-1-phosphate (S1P) inside cells. 


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#Section 2: General Biology

The amino group at C-2 bears a fatty acid in amide linkage.

The fatty acid is usually saturated or monounsaturated, with 16, 18, 22, or 24 carbon atoms.

Ceramide is the parent compound for this group.

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#Id: 8111

#Section 2: General Biology

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#Section 2: General Biology

Archaea membrane lipids are isoprene-based lipids.

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